Ccs1 gene
WebJan 24, 2003 · The Ccs1 gene, encoding a highly divergent novel component of a system II type c-type cytochrome biogenesis pathway, is encoded by the previously definedCCS1 … WebAbstract It has been shown that the activation of cytosolic superoxide dismutase (Sod1) in Saccharomyces cerevisiae is only dependent on Ccs1, which is responsible for insertion of copper into the enzyme catalytic center, and that glutathione (GSH) is …
Ccs1 gene
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CCS is localized in the nucleus, cytosol, and mitochondrial intermembrane space. CCS is imported to the mitochondria by Mia40 and Erv1 disulfide relay system. The cysteine 64 of CCS Domain I generates a disulfide intermediate with Mia40. This disulfide bond is transferred to link cysteine 64 and 27 of CCS, … See more Copper chaperone for superoxide dismutase is a metalloprotein that is responsible for the delivery of Cu to superoxide dismutase (SOD1). CCS is a 54kDa protein that is present in mammals and most … See more CCS is composed of three domains. Domain I is located on the N-terminus and contains the MXCXXC Cu binding sequence. It has been determined to be necessary for function of CCS but its specific role is currently unknown. The structure of domain … See more • Casareno RL, Waggoner D, Gitlin JD (Sep 1998). "The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase" See more In mammals cellular Cu levels are regulated by CCS's interaction with the 26S proteasome. During times of Cu excess CCS … See more • Human CCS genome location and CCS gene details page in the UCSC Genome Browser. See more WebApr 3, 2024 · 1 INTRODUCTION. Gaucher disease (GD) is the most common of the lysosomal storage diseases. GD is autosomal recessive, caused by mutations in the GBA1 gene (OMIM #606463), encoding the lysosomal enzyme acid β-glucocerebrosidase (also called β-glucosidase), which hydrolyzes glucosylceramide into ceramide and glucose. …
WebJul 18, 2024 · Recently, considerable attention has been paid to gene expression-based classifications of colorectal cancers (CRC) and their association with patient prognosis. In addition to changes in gene expression, abnormal DNA-methylation is known to play an important role in cancer onset and development, and colon cancer is no exception to this …
WebGene ID: 9973, updated on 29-Mar-2024. Summary. Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. ... CCS1 serves as a specialized import receptor in mitochondria that facilitates the import and ... WebGene target information for CCS1. Find diseases associated with this biological target and compounds tested against it in bioassay experiments. This application requires …
WebFeb 25, 2014 · Intriguingly, CCS1 encoding the copper chaperone for superoxide dismutase 1 (Sod1p) is necessary for cadmium resistance that is mediated by Ycf1p, a vacuolar cadmium sequestration transporter. ... To elaborate the possibility, we examined zinc resistance by the expression of ZRC1 gene encoding a vacuolar zinc importer .
WebSep 17, 2013 · The CCS1 rescue construct pJG111 for expression in C. albicans was generated by amplifying CCS1 gene sequences from −11 to the stop codon from … graphic card market shareWebFeb 7, 2014 · Copper chaperone Ccs1 is involved in the oxidative stress protection and has been characterized in S. cerevisiae [10]. It functions as a copper transporter for Sod1 [11]. Although Ccs1 share a significant sequence homology with Sod1, it has no superoxide dismutase activity. graphic card memeWebOct 3, 2008 · CCS1-related sequences were then searched in the K. lactis genome database to investigate if the overexpression of this chaperone could enhance heterologous protein production by itself. The Kl CCS1 gene was cloned and the deduced amino acid sequence showed a relevant closeness with Ccs1p from other yeasts, such as that from … graphic card manufacturer websiteWebThe growth and development of oocyte affect the functional activities of the surrounding somatic cells. These cells are regulated by various types of hormones, proteins, metabolites, and regulatory molecules through gap communication, ultimately leading to the development and maturation of oocytes. The close association between somatic cells and oocytes, … chip\u0027s rfWebApr 30, 2014 · Hybrids derived from wheat (Triticum aestivum L.) × rye (Secale cereale L.) have been widely studied because of their important roles in wheat cultivar improvement. Repetitive sequences pAs1, pSc119.2, pTa-535, pTa71, CCS1, and pAWRC.1 are usually used as probes in fluorescence in situ hybridization (FISH) analysis of wheat, rye, and … chip\u0027s rgWebFeb 1, 2003 · The Ccs1 gene, encoding a highly divergent novel component of a system II type c-type cytochrome biogenesis pathway, is encoded by the previously defined CCS1 … chip\u0027s rkWebDec 12, 1997 · The Ccs1 Gene Complements the Cytochrome b 6 f Complex and Cytochrome c 6 Deficiencies in abf3 A Southern blot analysis of DNA isolated from abf3 … chip\u0027s rn