Cisplatin liver toxicity

Author: iyhl

August undefined, 2024

WebCisplatin (CP) is a potent and extensively used chemotherapeutic agent. There is paucity of literature involving role of mitochondria in mediating CP-induced hepatic toxicity, and its underlying mechanism remains unclear. Oxidative stress is a well-established biomarker of the mitochondrial toxicity. WebNov 12, 2024 · Nephrotoxicity: cisplatin injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Consider dose reductions or alternative treatments in patients with renal impairment. Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy.

Carboplatin: Use, Dosage, Side Effects, Warnings - Drugs.com

WebCis-platin is an effective anti-neoplastic agent, but it is also highly nephrotoxic. Here, we clearly identify the human organic cation transporter 2 (hOCT2) as the critical transporter for cis-platin nephrotoxicity in isolated human proximal tubules and offer a potential mechanism for reducing nephrotoxicity in clinical practice. WebMar 9, 2024 · Cisplatin mediates nephrotoxicity via a number of different cytotoxic mechanisms. In addition to DNA damage, cisplatin also causes cytoplasmic organelle dysfunction, particularly in the endoplasmic reticulum and mitochondria, activates apoptotic pathways, and inflicts cellular damage via oxidative stress and inflammation [6]. chipotle fajita bowl

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WebDec 1, 2024 · Cisplatin-induced significant changes in the histopathological parameters of the liver, including remarkable vascular congestion, sinusoidal dilatation, and hydropic … WebOct 5, 2014 · Oxidative stress is the one of most important mechanisms involved in cisplatin toxicity. The mitochondrion is the primary target for cisplatin induced oxidative stress, ... Dimethylthiourea protects against mitochondrial oxidative damage induced by cisplatin in liver of rats. Chem.Biol.Interact. 2007; 170:177–186. [Google Scholar] WebApr 5, 2024 · Cisplatin mediates its tumorcidal effects via a number of different cytotoxic mechanisms. Although it is best known for DNA damage, cisplatin also causes cytoplasmic organelle dysfunction particularly with … chipotle family meal

Differential toxicity of cis and trans isomers of ...

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WebCisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast … WebWorld Health Organization grant thornton veraxWebApr 4, 2024 · Carboplatin can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve ). Tell your doctor about all your current medicines. chipotle family pack

"WebConclusions: We observed that there is an important relationship between CYP450 and cisplatin, involving increased toxicity. However, the possible mechanisms described for the involvement of CYP450 enzymes in nephrotoxicity and hepatotoxicity induced by cisplatin need to be confirmed by further studies. " - Cisplatin liver toxicity

Cisplatin liver toxicity

Targeted therapy for cisplatin‐resistant lung cancer via …

WebMar 2, 2024 · After several decades, cisplatin continues to be an essential drug for the treatment of several tumors, however, its potential nephrotoxicity is still a clinically … WebNov 7, 2024 · Hence, higher mitochondrial content directly correlates with sensitivity to cisplatin induced apoptosis. As mitochondrial reactive oxygen species are known to be toxic, we next analyzed the...

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WebCisplatin may be inadvisable if you have a history of severe allergic reaction to cisplatin, carboplatin, other platinum-containing formulations or mannitol. Do not receive any kind … WebJun 21, 2024 · Hepatoblastoma is a rare primary liver cancer with an age-adjusted incidence of 0.13 patients per 100,000 population. 1 Hepatoblastoma can be categorized as standard-risk or high-risk disease...

WebSome articles have reported severe toxicities induced by cisplatin/5-fluorouracil regimens, nevertheless, severe and lethal liver toxicity has not been previously reported. In this article, we report the case of a 72-year-old woman, who developed fulminant hepatitis, hypoglycemia and hypotension with atrial fibrillation not responding to treatment. WebFeb 11, 2024 · Cisplatin is a cytotoxic drug that triggers several toxicities. However, nephrotoxicity and ototoxicity remain major clinical limitations. The aim of our study was to evaluate the incidence of chemotherapy toxicity induced by cisplatin and to analyze the influence of risk factors in the Tunisian population.

WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). WebSep 15, 2024 · Liver injury from cisplatin is rare and when it does occur, the severity in published cases was generally mild and the outcome benign. There is likely to be cross sensitivity to liver toxicities of the various platinum coordination complexes and …

Web2 days ago · LiverTox®provides up-to-date, unbiased and easily accessed information on the diagnosis, cause, frequency, clinical patterns and management of liver injury …

WebOct 26, 2005 · It is possible that cisplatin-induced oxidative stress and CYP2E1-mediated oxidative stress synergize to produce hepatotoxicity. In the present study, the effect of increased CYP2E1 expression on cisplatin-induced hepatotoxicity was investigated. chipotle fallston mdWebToxicity evaluation study confirmed the safety profile of this combination therapy as OA in the dual-loaded NP system greatly reduced the cisplatin-induced hepatotoxicity. These results demonstrated that CDDP/OA-LCC NPs is an ideal approach in dealing with HCC alongside keeping the cisplatin toxicity parameters in check. chipotle farmlink projectWebThe RRs were 22% and 22%, respectively. One-year survival rates were 31% and 36%, respectively. What we have researched was Abraxane plus cisplatin and gemcitabine plus cisplatin, and their RRs were higher than ECOG 1594 clinical trials. The RR between the TP group and GP group also had significant difference. chipotle fairfieldWebPaclitaxel, Ifosfamide and Cisplatin Regimen is Feasible for —文档、资料、论文、办公、总结，均是精品资料，免费阅读，免费分享，值得下载！ chipotle famous dish grant thornton vat partnerWebThe heart, liver, lungs, spleen, and kidneys were histologically analyzed 30 days after injection with the indicated concentrations of the nano-zinc carrier. Some chronic toxicity was observed in the 10 mg/kg/d group, mainly in the liver and kidney (Figure S2B). Therefore, a concentration of 5 mg/kg/d was used in subsequent studies. grant thornton videoWebJan 29, 1998 · Cisplatin induces a persistent activation of JNK that is related to cell death Genotoxic stress triggers signalling pathways that either mediate cell killing or protection of affected cells. While induction of p53 is observed for most of the genotoxins, activation of MAPK/SAPK cascades is not a general response. grant thornton vat number