Flvcr1 choline
WebUpregulated FLVCR1 was positively correlated with lymph node metastasis (N stage) and late tumor-node-metastasis (TNM) stage. FLVCR1 knockdown inhibited cell proliferation … WebLong non‑coding RNA FLVCR1‑AS1 promotes glioma cell proliferation and invasion by negatively regulating miR‑30b‑3p . doi: 10.3892/mmr.2024.11149. Epub 2024 May 15. Authors Weida Gao 1 , Hongbin Li 2 , Yang Liu 3 , Yao …
Flvcr1 choline
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WebFeb 15, 2024 · FLVCR1-AS1 acted as an oncogene in GC via FLVCR1-AS1-miR-155-c-Myc signaling and may serve as a novel therapeutic target for treatment of patients with GC. … WebThis analysis revealed a connection between feline leukemia virus subgroup C cellular receptor 1 (FLVCR1) - a plasma membrane protein - and phosphocholine, a downstream metabolite of choline...
WebSep 7, 2024 · Potentially novel locus-metabolite associations were identified for FLVCR1 and choline, and for LPCAT3 and the lysophosphatidylserine 16.0, 18.0, 18.1, and 18.2; these associations are supported by published rare disease and mouse studies. WebDec 6, 2016 · Causative mutations were found in FLVCR1 (Feline Leukemia Virus subgroup C Receptor 1), a gene that has previously been associated to Posterior Column Ataxia and Retinitis Pigmentosa (PCARP)[11–16]. FLVCR1 is an ubiquitously expressed heme exporter[17, 18], member of the Major Facilitator Superfamily (MFS) transporters. Two …
WebMar 21, 2024 · FLVCR1-DT (FLVCR1 Divergent Transcript) is an RNA Gene, and is affiliated with the lncRNA class. Additional gene information for FLVCR1-DT Gene HGNC (39077) NCBI Entrez Gene (642946) Ensembl (ENSG00000198468) OMIM® (610864) UniProtKB/Swiss-Prot (Q8TAF5) Open Targets Platform (ENSG00000198468) Alliance … WebApr 18, 2024 · Moreover, this work revealed previously uncharacterized roles of FLVCR1 as a new choline transporter; CHEK1 as a post-translational regulator of the PC-synthetic …
WebFLVCR1 encodes for a transmembrane heme exporter protein and it is known to cause a rare form of syndromic retinitis pigmentosa: posterior column ataxia with retinitis pigmentosa. Recently, the FLVCR1-associated phenotype has been expanded with sporadic reports of hereditary sensory-autonomic neuropathy or non-syndromic retinitis pigmentosa.
WebTailor et al. (1999) functionally cloned a human cDNA encoding FLVCR1, a putative cell surface receptor for FeLV-C, from a T-lymphocyte cDNA library. The deduced 555-amino … floating shelves argos irelandWebMar 13, 2024 · Recently, mutations in FLVCR1 have been identified in several human diseases, 42, 43 but the detailed pathogenesis remains unclear. On the basis of our … floating shelves bagsWebFeline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoi … Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. floating shelves and vase displayWebFLVCR1, containing 12 hydrophobic transmembrane domains, is a member of the major facilitator superfamily and can transfer small solute molecules ( 6 ). FLVCR1 encodes two heme exporters, FLVCR1α localizing on the plasma membrane and FLVCR1β restricted to the mitochondria ( 6 ). floating shelves at kitchenWebMar 13, 2024 · A set of our experimental data revealed that FLVCR1 plays a critical role in the choline-uptake pathway of K562 cells and, therefore, is essential for cell proliferation … great lake constructionWebThe FLVCR1 gene encodes for two different isoforms which allows heme export through the plasma membrane (FLVCR1a) or out of mitochondria (FLVCR1b) in every cell type … great lake cruises for seniorsWebIntegrative genetic analysis identifies FLVCR1 as an essential component of choline transport in mammals - Genome-wide association studies (GWAS) of serum metabolites have the potential to uncover genes that influence human metabolism. Here, we combined an integrative genetic analysis . bioRxiv. Integrative ... floating shelves at hepo