Phospho-sting-s365
WebWhole cell lysates were analyzed by WB for phospho-STING (p-STING S365), STING, phospho-TBK1 (p-TBK1 S172), TBK1, phospho-IRF3 (p-IRF3 S396), IRF3, IFIT1, cGAS and FLAG (for disA expression). β-actin levels were used as loading control. Data are representative of three independent experiments. WebOct 24, 2013 · We conclude that phosphorylation of S366 (S365 in murine STING) occurs after autophagy and may negatively regulate STING activity to prevent sustained type I IFN production following activation by cytosolic dsDNA. ... 39-2700, used for murine IRF3); anti-IRF3 (Santa Cruz Biotechnology, sc-9082); anti-phospho-IRF3 (Cell Signaling, 4947); anti ...
Phospho-sting-s365
Did you know?
WebPhospho-STING (Ser365) (D8W4F) Rabbit mAb recognizes endogenous levels of STING protein only when phosphorylated at Ser365. Species … WebSTING is a four transmembrane (a.a. 21-41, 47-67, 87-106, 116-136) protein with both its N- and C-terminal ends exposed intracellularly (a.a. 1-20 and 137-379).The C-terminal cytoplasmic tail contains the c-di-GMP-binding domain (CBD; a.a. 153-340) with two c-di-GMP-binding regions (a.a. 162-167 & 238-241). Spécificité
WebJun 25, 2024 · In infected cells, STING is phosphorylated on S366 (S365 in mouse) and is K63 linked ubiquitinated, confirming the presence of its activated form at later time points following RNA virus infection, similarly to what has been observed by others after infection with DNA virus ( Chiang and Gack, 2024 ). Results WebPhospho-S365 acts as a docking site for IRF3, a transcription factor that is phosphorylated and activated by TBK1, leading to transcriptional induction of type I interferons (IFNs).
Webphospho irf 3 ser396 / stars Cell Signaling Technology Inc p irf3 P Irf3, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more Average Price from $ 2024-04 / stars Cell Signaling Technology Inc WebAnti-Phospho-STING-S365 antibody produced in rabbit. View Price and Availability. Sigma-Aldrich. ABF124. Anti-cGAS Antibody. from rabbit, purified by affinity chromatography. View Price and Availability. Sigma-Aldrich. D7290. Deoxyribonucleic acid from herring sperm. single-stranded for hybridization.
WebMouse Phospho-STING (Ser365) control lysateHTRF® This lysate is a component of the Mouse Phospho-STING (Ser365) kit. It may be used as a residue specific positive control …
WebMay 22, 2024 · Macrophage-stimulator of interferon genes (STING) signaling mediated sterile inflammation has been implicated in various age-related diseases. However, whether and how macrophage mitochondrial DNA (mtDNA) regulates STING signaling in aged macrophages remains largely unknown. bin brute force attackbin buddy festive sprayWebJul 7, 2024 · To initiate signaling, serine 365 (S365) in the C-terminal tail (CTT) of STING is phosphorylated, leading to induction of type I interferons (IFNs). Additionally, evolutionary conserved... cyrusher xf590 最高速WebPhospho-STING-S365 Rabbit pAb (AP1199) Western blot analysis of extracts of THP-1 cells, using Phospho-STING-S365 antibody (AP1199) at 1:1000 dilution.THP-1 cells were … binb speed readerWebPhospho-STING-Ser366 polyclonal antibody (Stimulator of interferon genes protein) binds to endogenous Stimulator of interferon genes protein only when phosphorylated at Ser366. Phosphorylation by TBK1 leads to activation and production of IFN-beta. Following cyclic nucleotide (c-di-GMP or cGAMP)-binding, activation and translocation from the ... b in bubbleWebRabbit Phospho-STING-S365 Rabbit pAb (AP1199), validaed in WB and tested in Human,, Mouse. 100% Guaranteed. ABclonal provides trial size antibody samples for target … bin buddy gryphonWebJan 29, 2015 · Phosphorylated (p-S365) or nonphosphorylated peptides (S365) were calculated by selectively using ions specific for each species (also see table S1 and … cyrusher xf590 plus