Polyductin
WebThe results indicate that polyductin is part of the group of polycystic kidney disease (PKD)-related proteins ex-Key words: ARPKD, PKHD1 gene, polyductin, fibrocystin, cilium, iso … WebFeb 9, 2024 · The predicted full-length protein (termed fibrocystin or polyductin) represents a novel integral membrane protein with a signal peptide at the amino terminus of its extensive, highly glycosylated extracellular domain, a single transmembrane (TM)-spanning segment, and a short cytoplasmic C-terminal tail containing potential protein kinase A …
Polyductin
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WebPolycystic liver diseases are hereditary disorders that affect the biliary epithelium, often in conjunction with the renal tubule epithelium. Characterized by the progressive formation of cysts throughout the liver and kidney, they can often … WebThere are two types of polycystic kidney disease (PKD).This section focuses on autosomal recessive polycystic kidney disease (ARPKD).Autosomal dominant, known as ADPKD, presents later in life, usually in adults.. Autosomal recessive polycystic kidney disease (ARPKD) presents in neonates and is usually picked up on antenatal ultrasound scans.It is …
WebSigns and symptoms. Symptoms and signs include abdominal discomfort, polyuria, polydipsia, incidental discovery of hypertension, and abdominal mass. The classic presentation for ARPKD is systemic hypertension with progression to end-stage kidney disease (ESKD) by the age of 15. In a typical presentation, a small number of individuals … WebSeveral proteolytic cleavages occur within the extracellular domain, whereas at least one cleavage occurs within the cytoplasmic domain (PubMed:16956880). Cleaved by a probable proprotein convertase which produces an extracellular domain (polyductin extracellular domain, (PECD)) and a C-terminal fragment (polyductin transmembrane fragment (PTM)) …
WebApr 26, 2024 · 3 S Puder et al used to analyze the overall cellular deformability of MDCK cells, in which the fibrocystin gene PKHD1 has been specifically knocked down (siPKHD1 … WebGeneral description. Fibrocystin (UniProt P08F94; also known as Polycystic kidney and hepatic disease 1 protein, Polyductin, Tigmin, TIG multiple domains 1, Tigmin) is encoded …
WebNov 27, 2009 · Reduced proliferation of FC1-depleted cells. a Downregulation of PKHD1 mRNA and FC1 protein in HEK293 and 4/5 (inset) cells stably transfected with either pSuper empty or PKHD1-siRNA a or b expressing plasmids. RT-PCR and Western blot analysis of membrane proteins were performed as described in “Methods”. Numbers above the blots …
WebThere are 19,576 search results, but Export to Excel supports up to 25,000. curationist.orgWebFeature papers represent the most advanced research with significant potential for high impact in the field. A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. easy dinner ideas for big familyWebFibrocystin. Fibrocystin is a large, receptor-like protein that is thought to be involved in the tubulogenesis and/or maintenance of duct-lumen architecture of epithelium. [5] FPC associates with the primary cilia of epithelial cells and co-localizes with the Pkd2 gene product polycystin-2 (PC2), suggesting that these two proteins may function ... easy dinner ideas for childrenWebThe PKHD1 gene provides instructions for making a protein called fibrocystin (sometimes known as polyductin). This protein is present in fetal and adult kidney cells, and is also … easy dinner ideas for dadsWebBased on the available data, ARPKD appears to result from partial or complete loss of polyductin/fibrocystin function. However, the mechanisms by which PKHD1 mutations cause clinical disease phenotypes are not well understood. Gene based analyses have been complicated by the large gene size and reported mutation detection rates have ranged … easy dinner ideas for hot daysWebOct 1, 2004 · Request PDF Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm PKHD1, the autosomal … curation foods guadalupe caWebAbstract details for Kidney Week 2024. Background. Human ARPKD (MIM 263200) is caused by mutations in PKHD1 (which encodes FPC), yet mouse Pkhd1 mutations cause minimal renal cystic disease. By contrast, Cys1 cpk/cpk (cpk) mice exhibit an ARPKD-like renal phenotype. The function of cystin (encoded by Cys1) is not fully understood, but the … easy dinner ideas for kids and adults